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And before we could clinically see that those drugs were not working, they were changing therapy to another therapy that bypasses in some way that estrogen receptor and those patients actually did better. They monitored these mutations over time and what they were able to show was that that patients on specific treatment, their cancers start to gain these mutations, and at some point when they were gaining these mutations, that's how those drugs weren't working anymore. We can do circulating tumor DNA from blood draws.
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And one of the trials that did that, the PALLAS trial in patients with metastatic estrogen-positive breast cancer, they looked at these mutations in the estrogen receptor, they're called ESR1 mutations, and they took blood because now we're lucky enough to not have to do biopsies anymore. What we're learning, and what we did this year more with these clinical trials that were presented, was monitoring the cancer throughout its course and seeing how it changes and adjusting our therapies based on those changes. And so, if we do a biopsy at the initial diagnosis, that cancer does not stay the same for the next 5, 10, 15 years. I think kind of the biggest theme that has been emerging in the past few years is how do we individualize our treatment to the specific patient and the specific time during their therapy? So, for example, we know that cancers evolve over time. So why don't we just start off with what I know our community wants to know most, which was what were the highlights for you from this very big meeting? Kaklamani, and I'm sure you're tired so thank you for making time for Living Beyond Breast Cancer.
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So, to read her full bio, which is very impressive, please go to our website,. So at least you didn't have to travel, right? She was one of the co-directors of the 2021 symposium, which I'm sure was a really challenging job this year, but in her day job, she is the professor of medicine at the division of hematology and oncology at the University of Texas Health and Sciences in San Antonio. Today we are extremely fortunate to have Dr. It also brings together advocates from all over the world and it's a very exciting meeting. It really brings the best minds together. I'm the CEO of Living Beyond Breast Cancer and today we will be talking about the 2021 San Antonio Breast Cancer Symposium, which for anyone in the breast cancer world this is the most important global meeting and often provides practice-changing information. She lives LBBC’s mission every day by speaking with newly diagnosed women about their needs and gaps in support. Jean brings a lifetime of women’s advocacy experience to her role as CEO.
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Jean began her work with LBBC in 1996 when she became the organization’s first executive director she was named CEO in 2008. Chief Executive Officer, Living Beyond Breast Cancer